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Manuscripts should be submitted with a letter specifying that the report is not under consideration . Elsevier JournalFinder helps you find journals that could be best suited for publishing your scientific article. Journal Pre-proof Immunoinformatics and Molecular Modeling Approach to Design Universal Multi-Epitope Vaccine for SARS-CoV-2 Md.Tahsin Khan, Md. endstream endobj 1785 0 obj <>stream Thank you for your feedback, it will help us serve you better. 1817 0 obj <>stream Journal Pre-proof COVID-19 in pregnancy: What we know from the first year of the pandemic Anya Lara Arthurs, Tanja Jankovic-Karasoulos, Claire Trelford �s��W�b���� ����ZWd�`�+Vws4; �v��$+�������!�xa.t> ��{������@����2i�N�69jI=�)e�i���d�`��)m�2І*x4��2v�29t��.�c�@�r���'��ŀ$ w�c0| ��K����#��yC��m��ׅ���+�Z� ��s��X�E^�,aj^��R�o����m4� V�R�Csw��>�P�U��Q�HEy=���*�[��eJ�Me`@��3t6rsg�[*��e �y��N��r)�>%}:��@��M���[�C�N��K3�=@��I�f`�c{{��nP���R�,����*�l1�t�n*�:Ӣ��������f vm�w�lbR��taq�����;�I�0쇜�? Terms and Conditions Privacy Policy Cookie Settings. Gonzalo Barge-Caballero, Eduardo Barge-Caballero, Manuel López-Pérez, Raquel . 523 0 obj <>stream Key engineering technologies to achieve green, intelligent, and sustainable development of deep metal mines in china. Guide for Authors updated 07 June 2021. �+7P�3CSz��?y��A�4KK+���0������c!|���{F�x�yED痧0:�������Og�����pQ"D���^{0�s����+���(������DZ���>�M� ~�ɣ��z���+�-^QT�+*rS\�:q������/VJ�S8K[�Vڰ� z�\��;�ܱ/�D.⻤�����i�U�-p�JE��?I�>a-�f��о�J(f�Ur�Id]��z��d;���$�7��5��dv��+��xK\�@{$"j�1u�=i��? Journal Pre-proof 2 1. Found insideThis book contains important coverage of environmental design, security surveys, locks, lighting, and CCTV, the latest ISO standards for risk assessment and risk management, physical security planning, network systems infrastructure, and ... B���w�]/�9�����-��ڀ��~p�}a�+�,w�B6���l�=����2�K����;�~�\r�+��5dӗ����.�� �z�9wt�(y���\�ߒ�[�X��Q=���HV=�v�s!���/����:���2��dݬz�\�:`�r:)�/i ҳ�����g�W�� R1c��!�-QH2�?�Z�\J�]# o;�e/� .�e�J��G��vM�7U�-K�� /�u���H0�^Y�+F)�n1Z-n�W_�pd~�(1m�I���! The Routledge Handbook of Research Methods in Applied Linguistics provides a critical survey of the methodological concepts, designs, instruments and types of analysis that are used within the broad field of applied linguistics. Journal Pre-proof 1 SARS-CoV-2 in wastewater: State of the knowledge and research needs Masaaki Kitajima,a,* Warish Ahmed,b Kyle Bibby,c Annalaura Carducci,d Charles P. Gerba,e Kerry A. Hamilton,f Eiji Haramoto,g Joan B. Roseh a Division of Environmental Engineering, Faculty of Engineering, Hokkaido University, North 13 West 8, Kita-ku, Sapporo, Hokkaido 060-8628, Japan E. Elsa. The journal focuses on both experimental and theoretical studies on the biology, chemistry, biosynthesis, metabolism, molecular biology, physiology and pharmacology of …. This book focuses on those organic chemicals that are regulated by the Stockholm Convention on Persistent Organic Pollutants (POPs). as well as organic chemical with the attributes of being persistent, bioaccumulative, and toxic to ... While there are books treating individual topics contained in this book, this will be the first single volume providing a cohesive treatment on this subject as a whole. Journal Pre-proof 5 sandstones and conglomerates, with intercalations of thin siltstone beds, with a total estimated thickness of 200-300 m (e.g. This volume provides a state-of-the-art review of the relationship between technology and economic growth. Many of the 42 chapters discuss the political and corporate decisions for what one author calls a "Competitiveness Policy. Found insideIn joint replacement surgery with suboptimal bone, allograft materials are often used to achieve biological fixation of the metallic implant to the host bone and reducing the implant fixation time. For example, supplementary files may still need to be added, links to references may not resolve yet, etc. Elsevier Product Insights for Customers. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. These include danoprevir/ritonavir, azvudine, sofosbuvir/ledipasvir, sofosbuvir/daclatasvir, darunavir/cobicistat and Emtricitabine/Tenofovir (Table 1A: Antivirals). H��U�r�0��:Z3X�%ْ� m3�$�N˴�$� )� ���wWZ#`zA�%�}�v�¦W��Mg~v�Z|����O�F��2�E��F&��n�/\ ɒ-O�XҬy�EŒ�ћ��%c�0XK�yZ If you decide to participate, a new browser tab will open so you can complete the survey after you have completed your visit to this website. A comprehensive review of unit roots, cointegration and structural change from a best-selling author. Elsevier eBooks for Practicing Clinicians. h�bbd```b``�"������L��E. View full aims & scope. %%EOF Setting The Mayo Clinic is comprised of three major campuses located in Rochester, Minnesota, Florida, and Arizona, as well as multiple Mayo Clinic Health System (MCHS) hospitals and clinics They have undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but are not yet definitive versions of record. Found insideThis book forms essential reading for all students on academic writing and EAP courses or who wish to improve their writing. The criteria for acceptance are originality and high scientific quality. Elsevier Text Mining. H��UKo�0��W�h���_C�C6�@������Σk� IW�ߏ�(9N����H~��QH��~���2�� x�c2�P���D��L��H������;I�E���ۘw6ƻ'�;�*aK�#��r�_G DP6��ޱ,s���BX��z���8�����z�;�F��(����&?��p~>���v F����5~'g��gu!,$�e��L���\T�Hbv�M��@:{���x�M�+�H1_��gV�T Ɍ}��DŽ�Uޒ��|���B�55d5�u�=�u=��9�V�Ϝ�d8�����G���f�s���5���{�t�����{b9`T�%b�����'��Xx��u߰ЌB�TU`6LYh�t��NJ�&w=P�7}6�a��ͭ�PQY�g/� A�,p[�Br:@Qp��(=ژS�Ce�L��W�cT���(#�t�����|�o#T���fH|����pu��8����c�?�+�7��;�[���;XM�&�}�!�p�4��\RY!+�6����`|V���0 c����v���(�����x�*Q�y�;�8�[�A�-��v�s��jɛ�(�Xs��͒>\�P��ru/wIJ!,���BTl6μ,"�\�t�1hx�i4� Journal Pre-proof 1 A critical assessment on experimental investigation of dynamic recrystallization of metallic materials H.K. The guest editors for this issue are Margaret MacLean (Strathclyde), Rhian Touyz (Glasgow)and Steeve Provencher (Quebec). This book analyses the English writing and publishing experiences of 118 scholars from 18 Chinese universities from a social-cognitive perspective. Journal Pre-proof Efficacy of a Low Dose of Melatonin as an Adjunctive Therapy in Hospitalized Patients with COVID-19: A Randomized, Double-blind Clinical Trial Gholamreza Farnoosh , Mostafa Akbariqomi , Taleb Badri , Mahdi Bagheri , Morteza Izadi , Ali Saeedi-Boroujeni , Ehsan Rezaie , Hadi Esmaeili Gouvarchin Ghaleh , Journal Pre-proof 3 Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel betacoronavirus that was first described in a cluster of patients presenting with pneumonia symptoms in Wuhan, China (1) in Uncorrected proofs are Articles in Press that have been copy-edited and formatted, but have not been finalized yet. The expression of MIF and its binding partners has been characterised These versions will undergo additional copyediting, typesetting and review, and may not yet have full ScienceDirect functionality. Journal Pre-proof 3 Introduction . Journal Pre-proof. Proof Central always makes it possible for you to provide your corrections through an online mode. This book provides a timely synthesis and critical assessment in order to generate a consensus on the main issues involved and stimulate new perspectives for future research. U ��������`U�s� ��ې�*�����ɸ}s��� �F�* �@�i�g���J�ُ]���Ю̚P��Ԡ'נ�:%�T j��HP�-F ���0�6 �4v~{3���4O:I�؋-w��v^�-�&���~'��WF�+)�=�rw�qB����A�C}��H5c�t �r� As the COVID19 global pandemic rages across the globe, the race to prevent and treat this - deadly disease has led to the "off label" repurposing of drugs such as hydroxychloroquine and - lopinavir/ritonavir with the potential for unwanted QT interval prolongation, anda risk of drug- induced sudden cardiac death. The intense volcanism of this area has been related to the existence of a low-velocity zone at mid-crustal levels known as the endstream endobj 1788 0 obj <>stream To post social content, you must have a display name. Journal Pre-proof How COVID-19 highlighted the need for infection prevention and control measures to become central to the global conversation: experience from the conflict settings of the Middle-East Roula El Mouallem , Krystel Moussally , Anita Williams , Ernestina Repetto , Marilyne Menassa , Chiara Martino , Ghassan Abu Sittah k��=�-��侶:�a�5���6�K�0}�,�c������ʍ�q��g x��gN6+�+��� ��P��?8�u ˱/|O+W��j��>������U�"�� �̾br%t��%C���DߔUw�.��~@��)2�#���^��!���-V".�ף>Ě*��V#&�NkQ����]�u_��3���A Elsevier E-Commerce. ;&�%�i�xn��}�G�� Journal Pre-proof Light-guided nudging and data-driven performance feedback improve hand hygiene compliance among nurses and doctors Anne-Mette Iversen RN, MSc , Marie Stangerup RN , Michelle From-Hansen RN , Rosa Hansen RN , Louise Palasin Sode RN , Krassimir Kostadinov MD , Marco Bo Hansen MD, PhD , Henrik Calum MD, PhD , !�b�ͺ��5\���.4w~7=�L�ϋԥ���ԩ5bZKfW�� � ��35U�F�Ԝ�0��Dʥ�oC��̿�@q��0���ק0}�������H��'g�2iei�\;^b�0����5��X��၏D�Д�G����0��( X��7[�/:���� �hHߩs��f��`������7�CD0VC܂p?M��[�G�O�x�D�m�7�[X��xk�k-"��l�O�>�_�=�χD`�l�l��>Nq��/��8�m5֙4���u��5�{�2��o���!�5N�g|�U���%��x�-�_'��ſqEC��KK'%�UOH��=�%sp�M�~W�eW3�Τ�M�P�hU�\Q�g;´�������).�'� �c�I If you require assistance, please scroll down and use one of the contact options to get in touch. Found insideAll these subjects require very similar numerical methods and this is why they are treated together in this book. Therefore, I have preferred to use the term computational hydraulics. We would like to ask you for a moment of your time to fill in a short questionnaire, at the end of your visit. Last updated on July 29, 2021. The common thread of articles published in Decision Support Systems is their relevance to theoretical and technical issues in the support of enhanced decision making. Accepted articles are published in-press and pre-proof stage immediately after acceptance. Journal Pre-proof Mercury-induced autoimmunity: Drifting from micro to macro concerns on autoimmune disorders Geir Bjørklund, Massimiliano Peana, Maryam Dadar, Salvatore Magnetic Nanomaterials in Analytical Chemistry provides the first comprehensive review of magnetic nanomaterials in a variety of analytical chemistry applications, including basic information necessary for students and those new to the ... American Journal of Obstetrics & Gynecology is pleased to announce it reaches over 43,000 readers, including general ob-gyns, maternal-fetal medicine specialists, reproductive endocrinologists, gyn oncologists, and others. Journal Pre-proof Non-alcoholic fatty liver disease Stratification by Liver Lipidomics Olga Vvedenskaya, Tim Daniel Rose, Oskar Knittelfelder, Alessandra Palladini, Judith Andrea Heidrun Wodke, Kai Schumann, Jacobo Miranda Ackerman, Yuting Wang, Canan Has, Mario Brosch, Veera Raghavan Thangapandi, Stephan Buch, Thomas Read more. Why: Hydroxychloroquine is a more soluble hydroxy-analogue of chloroquine (CQ), which was first Journal Pre-proof 2 1. It welcomes: new knowledge about humanity's diverse anticipatory practices and how to …. Sharing information about the risks of binge drinking from a public health media campaign may help Anna convince Julie to stop drinking. This volume was written to make the case for changes in second language writing practices away from the five-paragraph essay and toward purposeful, meaningful writing instruction. Are you sure you do not want to provide feedback? 19 (2020). This book summarises key research in palladium membrane technologies, with particular focus on the scale-up challenges. After an introductory chapter, Part one reviews the fabrication of palladium membranes. 497 0 obj <>/Filter/FlateDecode/ID[<198BC602204F6541A2C14DECB07FFC77><87DF669335AF9D4C801593F2DB9C05BF>]/Index[462 62]/Info 461 0 R/Length 141/Prev 1597866/Root 463 0 R/Size 524/Type/XRef/W[1 3 1]>>stream Introduction The retrofitting, rehabilitation and strengthening of damaged or deteriorated metallic structure is an important subject [1-3]. Journal Pre-proof Kidney Transplant T-Cell-Mediated Rejection Occurring After Anti-CD19 CAR T-Cell Therapy for Refractory Aggressive Burkitt-like Lymphoma With 11q Aberration: A Case Report Tristan de Nattes, MD, Vincent Camus, MD, Arnaud François, MD, Grégoire Dallet, MD, Christophe Ferrand, MD, PhD, Dominique Guerrot, MD, PhD, Mathilde . The areas addressed may include foundations, functionality, interfaces, implementation, impacts, and evaluation of decision …. Journal Pre-proof 2 APVC (latitude 21-24°S, the Andes) produced more than 15,000 km3 of crystal-rich dacitic ignimbrites (e.g., de Silva et al., 2015) originating mostly from calderas. Viral Infection Infects Macrophages Dendritic Cell APC of Antigen Presentation ro T-Cells -p re Activation Differentiation lP na MAPKs NF - kB IRF3 ur Jo Inflammation Journal Pre-proof Figure3: Proteases IL-6 Degranulation IL-1 IL-33 Mast cell Histamine Degranulate mast cell of Activation of T-cells Differentiation of T-cells ro Virus response . Read more. Futures: For the interdisciplinary study of futures, anticipation and foresight. Journal Pre-proof. h��VmS�H�+�Qk˛��VmQ"蝂�{K�!��2$Vw���D��Ñ�ӯ�3��DzB3��',&�D�f���p��.��F�c�!��,,d����wG 8���"��@^w{�d^2�. About the journal. ͒;U�U���%o������1�1�dO@M �i��W� endstream endobj 463 0 obj <. endstream endobj 1787 0 obj <>stream Annals of Oncology publishes manuscripts that describe new findings of particular significance in any area related to clinical oncology and clinically-oriented basic cancer research. 1802 0 obj <>/Filter/FlateDecode/ID[<8C6248A7DBE2F949A64F477867FA34DC>]/Index[1780 39]/Info 1779 0 R/Length 115/Prev 1435544/Root 1781 0 R/Size 1819/Type/XRef/W[1 3 1]>>stream { In Press, Journal Pre-proof, Available online 16 August 2021. {�j�^� '{� .�t���*TP)4�"��Z-P+s� ��4y��|�����i��d��`0��"�2�z��-G�N�E���]��t�[�t�p K���GQ���mh~�.���ulL��q��M�E�0�f���G87�~6��-R G�1�D�t� ���6�>�^K��WL�q����� { ����=��b)���v���! Journal Pre-proof. 1 Article Type: Original article Article Title: Deep Learning for Basal Cell Carcinoma Detection for Reflectance Confocal Microscopy. Publ ished by Elsevier Ltd . Journal Pre-proof. Yet, the prevailing social norm among endstream endobj 1789 0 obj <>stream For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. Journal Pre-proof It's Time to Reconsider How We Define Health: Perspective from Disability and Chronic Condition Gloria L. Krahn, Ann Robinson, Alexa J. Murray, Susan M. Havercamp, The Nisonger Subscription articles. �:z�ڳ(Y�~Lt.y���~��>�U���z�����Y��#�� _��x⩣�u�Ѻ�D҇����ZMwװݛ%��)U�/���7���=cl���)R��;iAa%�)�X�������8�K��nh � �5��/�k!˘���U�b�W�naAA��D��W:gn|'����B�/t�P�H�}� T�"� 6�u�E����0g�闖0XH��dde}2��읒�[�w�Sl��G�pY����3}�/�0��fA��Lk�{�y`�iǤ�2��� N� This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. The text could still change before final publication. The expression of MIF and its binding partners has been characterised ���ո̔�̭�ʴiGq���4�D���2�1�[�¤�a�K�&����E�X�z&R�u���^W�o}� lfS��B7:�u��m&���Yl�lL��+J����ti�v��!��ަ��4ǫ��Q�;�D�a� c�ln�a,0�e[��M�k���"�P��5 �Rj�`nY4��t�ꐲbX��W���e�+\\#� �C��4TۆM#3=�S߉�h��� �8��Mj7�p�h��|�&Af��X*Eh+Ԉ���B����e����96NB���+qs����v@1��q?~�e���u�W!D�p�/VB+6�1�X��~( 4N*N����� �*�S�j�$�ݹ��j��T���L��8��ʁ�����+�i���?�����+z�s�8�c��]����L��>m�:�i��P�v��Y}$x��? Traditional strengthening methods for steel structures include crack arresting hole, improving geometric continuity, bolted and welded metallic plates, etc. Macrophage migration inhibitory factor (MIF) is an important regulator of innate immunity with key roles in neural regeneration and responses to pathogens, amongst a multitude of other functions. Where do firms turn for financing in countries with poorly developed financial markets? One source is trade credit. And where formal financial intermediaries are deficient, industries that rely more on this source of financing grow faster. Although uncorrected proofs do not have all bibliographic details available . Journal Pre-proof Discussion of "Accurate explicit analytical solution for Colebrook-White equation" by Zahreddine Hafsi, Mechanics Research Communications 111 (2021) 103646) . 亸9̪�7� ��^���)+&���xr5�������:�6��d{f�o>`s ��Ԅ)��J֘��@�X�Y���g�����RIJ,�4(�$�-oxА��W`d#J�9�/N���?wW��PA�q2�pOZ�d����B�)f��WE aOX����� ����]��c��tE�����ˌW���7T�����H.�?�`�I��V�B��dF��pI,�϶+A`��'q5}�Ӧ ր�����$*�U��Na �h*�I�������W�zJ��JeZ���_ .tos(ȡ@e��ɕPEQ�Y �����f;_��Ӗ8�-����]�@d�� ��� �~:sq��k�y��U�G� � Elsevier Ordering Platform. Bilbao-Quesada, Eva González-Babarro, Inés Gómez-Otero, Andrea López-López, [4-6]. �9�Zb����%o�f[���. `�ϑ�B(h�L�o\�h&��⊕�WP,�� Journal Pre-proof Society for Maternal-Fetal Medicine Special Statement: Checklist for initial management of amniotic fluid embolism C. Andrew Combs, MD, PhD, Douglas M. Montgomery, MD, Lorraine E. Toner, MD, Gary A. Dildy, MD, Patient Safety and Quality Committee, Society for Maternal-Fetal Medicine PII: S0002-9378(21)00001-6 The second half surveys the empirical data on social capital in key health areas. Among the highlights: Toward a definition: Individual or group entity? Negative as well as positive effects? Please direct these inquiries to Professor Mandy MacLean [email protected]. Introduction The retrofitting, rehabilitation and strengthening of damaged or deteriorated metallic structure is an important subject [1-3]. Found inside â Page iiWritten in an accessible style and suitable for final-year undergraduate and Masters-level students, the book includes clear definitions of key terms, discussion questions for classroom use, practical exercises and activities, and examples ... Futures aims to build substantive research and knowledge about the relationships between humanity and its possible futures. Beta-Blocker Exposure and Survival in Patients With Transthyretin Amyloid . Found insideA sustained critique of mainstream economic theory and discussion of the development of an alternative. Annotation copyrighted by Book News, Inc., Portland, OR Journal Pre-proof Congenital Heart Surgeons' Society prospective atrioventricular septal defect cohort was also supported by funding from Children's Minnesota, Minneapolis, MN. Pre-submission inquiries are encouraged. endstream endobj 1786 0 obj <>stream %PDF-1.6 %���� Jahirul Islam, Arpana Parihar, Rahatul Islam . endstream endobj 1784 0 obj <>stream Journal Pre-proof Long term survival with regorafenib: REALITY (Real life in Italy) triala GISCAD Study. ''As the summary of a vision, the book is brilliant. Journal Pre-proof 1 Development of the eTAP-T: A Measure of Mental Health Professionals' Attitudes and Process Towards e-Interventions Bonnie A. Clough* 1, 2, Dale P. Rowland 1, 2 & Leanne M. Casey 1, 2 1 School of Applied Psychology, Griffith University, Australia 2 Menzies Health Institute Queensland, Australia * Correspondence to: Dr Bonnie Clough Proofing modes. In this special volume on polymer particles, recent trends and developments in the synthesis of nano- to micron-sized polymer particles by radical polymerization (Emulsion, Miniemulsion, Microemulsion, and Dispersion Polymerizations) of ... The date the article was first made available online will be carried over. About the journal. Introduction The Third Pole is the water tower of Asia and encompasses the Himalaya-Hindu Kush mountain ranges and the Tibetan Plateau (Zhang et al., 2019b). Download PDF. W�6{��7�J�[� Read more. Journal Pre-proof Keywords: GRACE, Groundwater, mascon, PCA, quantile function of storage, surface water 1. If you are an author, please share a link to your article rather than the full-text. Journal Pre-proof Kidney Disease, Hypertension Treatment, and Cerebral Perfusion and Structure Manjula Kurella Tamura, MD, MPH, Sarah Gaussoin, MS, Nicholas M. Pajewski, 2 51 1. Elsevier Access. Zachi I. Attia, PhD, Suraj Kapa, MD1, Jennifer Dugan, BA, Naveen Pereira . MNx��ll�+�Z������>Tp� ��oi�Hצ鶤��b6�� W��쁥�}���8Gp&��J��V;���� ��Ayϝv�g(�o����>s��${幞ь#���.k[ �0*j��+�.q�LW��-���q��u�����6����U�r.&� �y�~�pi#�ۈ4�`��d{"lj��k�!D�&9Y �{ZEvq5c$�)ޔ�� B��� Meifeng Cai, Peng Li, Wenhui Tan, Fenhua Ren. Found insideSustainable Use of Chemicals in Agriculture, Volume 2, explores the wide breadth of emerging and state-of-the-art technologies used to study the sustainable use of chemicals in agriculture. Journal Pre-proof Getting "Our House" in Order: Re-building Academic Pediatrics by Dismantling the Anti-Black Racist Foundation Monique Jindal MD , Nia Heard-Garris MD, MSc , Introduction 52 53 The deposition of extensive evaporite (salt) deposits is a common occurrence during and after 54 continental break-up and the associated marine transgressions. The COVID-19 resource centre is hosted on Elsevier Connect, the . Examples of such evaporite 55 deposits are found at numerous passive margins around the world (e.g. Measurement: Sensors is a companion journal to Measurement: Journal of the International Measurement Confederation (IMEKO) . Journal Pre-proof STRESS AND SYMPTOM BURDEN IN ONCOLOGY PATIENTS DURING THE COVID-19 PANDEMIC Christine Miaskowski, RN, PhD, Steven M. Paul, PhD, Karin Snowberg, MA, Maura Journal Pre-proof 1 Voltammetric study of triazole antifungal agent terconazole on sp3 and sp2 carbon-based electrode materials Jan Fischer a, Javier González-Martín a,b, Pawel Lochyński c, Hana Dejmková a, Karolina Schwarzová-Pecková a, Marisol Vega b,d* a Charles University, Faculty of Science, Department of Analytical Chemistry, UNESCO Our circulation is audited by BPA who confirms these numbers. Pre-print - A pre-print is the original version of the manuscript as it is submitted to a journal. Journal pre-proof DOI: 10.1016/j.immuni.2020.04.018 This is a PDF file of an accepted peer-reviewed article but is not yet the definitive version of record. Journal Pre-proof. Parkinson's disease (PD) is a multi-system proteinopathy reflecting the progressive loss of dopaminergic nigrostriatal neurons causing a variety of motor deficits, including resting tremor, Fang1, Q. Zhang1, R. E. Logé3, K. Huang1*, 3 . 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